Next-Generation Sequencing
calendar_month 29 Iul 2015, 00:00
The course will start with an overview of current NGS technologies and directions in which these are currently progressing. Methods for assembling genomes from NGS data using either a reference genome or de novo assembly will be presented together with some emphasis on assessing NGS data quality (Quality control, accuracy of base calling). The course will then offer an overview of the range of biological/biomedical questions that these new types of data can help to address. This includes: The use of NGS resequencing of closely related genomes for detecting mutations. This includes the characterization of somatic mutations in cancer tissues, the de novo mutation spectrum in eukaryotic genomes, and the detection of mutations underlying phenotypic changes in experimental or natural populations.Combining NGS with methods aimed at reducing genome complexity such as exome resequencing in complex genomes.The use of resequencing of a large number of individuals for Single Nucleotide Polymorphism (SNPs) and Copy number variation detection.Application of NGS in Transcriptomics, Epigenomics and Chromatin structure studies. Environmental/Meta-genomics studies probing the bacterial/viral diversity of understudied biomes.Comparative and evolutionary genomics.

Course leader
Teacher: Mikkel Heide Schierup:

Target group
Master's level.Students holding a relevant Bachelor's degree.

Fee info
EUR 133: Price: Students holding a preapproval including exchange students do not pay for the course.ONLY Free-mover students and Tomplads students MUST pay for the course: Danish and EU/ES (tomplads): 133 EURNON-EU-ES students (free-mover): 1050 EURBooks, course materials, social programme, and housing are not included in the tuition fee. Also be aware of course specific expenses mentioned in the description.

No scholarships available.

Aarhus University
Address: International Centre, H%C3%B8egh Guldbergsgade 4-6
Postal code: 8000
City: Aarhus
Country: Denmark
Phone: +4551335274