Translational courseMitochondria are central to the regulation of cellular growth and energy production. The abnormal functioning of these organelles and associated pathways is closely linked to neuromuscular disease, ageing, cancer and metabolic syndrome/diabetes.This translational course explores mitochondrial bioenergetics from the perspectives of research, diagnostics and the clinic; from molecule to man to population. Thanks to an interactive programme, this course goes beyond the textbook to actively engage you in state-of-the-art laboratory and clinical practices.Interactive programme at the Radboud University Medical CenterEach course day covers research, diagnostic and clinical aspects of this field and stresses the value of combined approaches:During the research sessions, which start with an introduction to cellular bioenergetics, we will focus on the mitochondrial oxidative phosphorylation (OXPHOS) system, (the plasticity of) mitochondrial structure/microscopy, mtDNA genetics, maintenance & gene expression, biogenesis of the OXPHOS system, protein dynamics and drug development. The diagnostic sessions will highlight new and existing genetic and biochemical diagnostic approaches, with a special focus on the development of biomarkers for disease. During the clinical sessions you will be introduced to the clinical presentation of mitochondrial disorders, the personal perspective of the patient, anamnesis, clinical guidelines, case reports, treatment options, trials and the development of outcome measures. As part of the course, you will be expected to develop a translational mini-project in pairs and present your results during our final lesson.After this course you will be expected to understand the essence of translational research in a full facility centre and think and behave as a (junior) scientist in the field.
Period11-08-2014 - 15-08-2014 (1 weeks)
Target groupMaster's students studying (bio-molecular) life sciences and medicine in the final phase of their Master's degree who are considering a PhD in the field of metabolic disorders
Course aimAfter this course you will be able to:1. Understand the basic functions of mitochondria in cellular metabolism and additional processes2. Understand the molecular basis of mitochondrial disorders and their clinical consequences3. Describe current possibilities and developments in the field of diagnosis, treatment and prevention of these diseases4. Appreciate the value of an interdisciplinary approach to combating disease
Credits2.0 ECTS credits
Course feeEUR 550[Convert to USD]The course fee includes the registration fee, course materials, access to library and IT facilities, coffee/tea, lunch, and a number of social activities. The fee does not include accommodation, travel costs, dinner, insurance and other costs. In some cases travel costs might be reimbursed, for more information please contact Dr. ir. Rutger Vogel at Rutger.Vogel@radboudumc.nl Discounts10% discount for early bird applicants. The early bird deadline is 1 April 2014.15% discount for students and PhD candidates from Radboud University and partner universities
Course leaderProf. Dr. J. (Jan) Smeitink, Professor of Mitochondrial MedicineRadboud university medical centre
Radboud UniversityAddress: P.O Box 9102 Nijmegen
Postal code: 6500 HC
City: Nijmegen
Country: Netherlands
Website: http://www.ru.nl/radboudsummerschool/
E-mail: radboudsummerschool@ru.nl
Phone: +31 (0)24 8187706
